Learn about possible serious side effects
Each person responds differently to treatment, so make sure to talk to your doctor about how you’re feeling. This is a summary of important risk information about BRAFTOVI (encorafenib) + MEKTOVI (binimetinib). If you experience any of these symptoms while taking BRAFTOVI + MEKTOVI, call your doctor immediately.
Risk of new skin cancers |
Symptoms included new warts; skin sores or reddish bumps that bleed or do not heal; change in size or color of a mole. |
Heart problems, including heart failure |
Symptoms included feeling like your heart is pounding or racing; shortness of breath; swelling in the ankles and feet; feeling light‑headed. |
Blood clots |
Can lead to death. Symptoms included chest pain; sudden shortness of breath or trouble breathing; pain in your legs with or without swelling; swelling in your arms and legs; a cool, pale arm or leg. |
Bleeding problems |
Can lead to death. Symptoms included headaches, dizziness, or feeling weak; coughing up blood or blood clots; vomiting blood or your vomit looks like “coffee grounds”; red or black stools that look like tar. |
Eye problems |
Symptoms included blurred vision, loss of vision, or other vision changes; seeing colored dots; seeing halos (blurred outline around objects); eye pain, swelling, or redness. |
Lung or breathing problems |
Symptoms included shortness of breath and cough. |
Liver problems |
Symptoms included yellowing of the skin or white part of the eyes (jaundice); dark or brown (tea-colored) urine; nausea and vomiting; loss of appetite. |
Muscle problems (rhabdomyolysis) |
Symptoms included weakness; muscle aches or pain; dark, reddish urine. |
Changes in the electrical activity of your heart (QT prolongation) |
Can be life-threatening. Symptoms included feeling faint, light-headed, dizzy, or if you feel your heart beating irregularly or fast. |
Risk of harm to unborn babies |
Tell your doctor if you are pregnant or plan to become pregnant. |
These are not all of the possible side effects with BRAFTOVI + MEKTOVI.
Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.
The most common side effects
The most common side effects that people experienced in a clinical trial while taking BRAFTOVI + MEKTOVI are below. ClickTap on the below for information about side effects to discuss with your doctor.
Remember, the information below does not replace directions from your doctor. Always talk to your healthcare team about side effects and ways to manage them. Your doctor may change your dose or stop treatment temporarily or completely. Before taking any medications, speak with your doctor.
FatigueTalk to your doctor if you experience fatigue. They may recommend daily exercise or other activities that may help reduce fatigue. |
HeadacheTell your doctor about any headaches right away as they may be serious. They may suggest daily rest or other activities that may help reduce headaches. |
Abdominal pain/nauseaAbdominal pain and nausea may be worse if your stomach is empty. Discuss your eating habits with your doctor to see how you can make adjustments. They may suggest avoiding foods that commonly cause abdominal pain and eating smaller meals throughout the day. They may also suggest an anti-nausea medicine. |
VomitingIt’s important to stay hydrated throughout treatment. Talk to your doctor about liquids and over-the-counter medicines that may help. Fruit juices, ginger ale, water, and sports drinks are often recommended as they can help prevent dehydration. |
Pain or swelling of jointsYour doctor may recommend physical therapy or medicine to reduce swelling and inflammation. They may also suggest light stretching and hot or cold compresses to help reduce joint pain. |
Fever or chillsTalk to your doctor about any fever or chills right away. They may recommend rest, fluids, and over-the-counter medicines. As soon as you sense a fever coming on, check your temperature and keep a record of it in your journal. |
RashTell your doctor about any rashes right away. They may recommend creams or lotions to soothe it, or wearing clothing of a different material, as well as avoiding excess time in the sun. |
DiarrheaYour doctor may suggest you take over-the-counter anti-diarrheal medicine to help, but it’s also always important to stay hydrated. Sports drinks are often recommended as they can help replace electrolytes and salts. Report diarrhea to your doctor right away. |
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